abstract：:A gamma-scintigraphic study was carried out in 13 healthy individuals to compare the lung deposition of budesonide from a novel multidose dry powder inhaler (MDPI; Novolizer) with that from the Pulmicort Turbuhaler, and to assess the degree of flow rate dependence of the Novolizer. Median whole lung depositions for th...

journal_title：Current opinion in pulmonary medicine

authors： Newman SP,Hirst PH,Pitcairn GR

更新日期：2001-04-01 00:00:00

abstract：:Lung volume reduction surgery and lung transplantation have been shown to improve lung function, exercise capacity, and quality of life in patients with advanced emphysema. Because the indications for both surgical procedures overlap, lung volume reduction surgery may be used as an alternative treatment or as a "bridg...

journal_title：Current opinion in pulmonary medicine

authors： Cordova FC,Criner GJ

更新日期：2001-03-01 00:00:00

abstract：:The neurotrophins are a family of peptides that promote survival, growth, and differentiation of neurons. Neurotrophins may also influence the function of nonneuronal cell types, including immune cells. The development and maintenance of asthma is thought to involve the nervous system and the immune system, but the ro...

journal_title：Current opinion in pulmonary medicine

authors： Carr MJ,Hunter DD,Undem BJ

更新日期：2001-01-01 00:00:00

abstract：:Disorders of sleep in children are distinctly different from sleep disorders in adults. Since children are forced to constantly learn and adapt, the effects of disordered sleep may be more profound. This paper reviews the disorders of sleep that are most significant in each of the stages of development from infancy to...

journal_title：Current opinion in pulmonary medicine

authors： Anstead M

更新日期：2000-11-01 00:00:00

abstract：:Interstitial lung diseases are characterized by disruption of the distal pulmonary parenchyma. The clinical history manifestations, cough and dyspnea, and physical exam manifestations, inspiratory crackles, are nonspecific. Pulmonary function testing aids in the evaluation and management of patients with interstitial ...

journal_title：Current opinion in pulmonary medicine

authors： Flaherty KR,Martinez FJ

更新日期：2000-09-01 00:00:00

abstract：:The bacillary population described in tuberculous pleuritis is small, and its most likely pathogenetic mechanism is essentially immunologic. This explains why, until now, the diagnostic identification of tuberculous pleuritis (TP) has been based on the presence of granulomas in pleural biopsy. Correcting this diagnost...

journal_title：Current opinion in pulmonary medicine

authors： Pérez-Rodriguez E,Jiménez Castro D

更新日期：2000-07-01 00:00:00

abstract：:While the most recent trend in secondary prophylaxis after venous thromboembolism has been toward a prolonged duration, it has become obvious that individualization according to risk factors is crucial. Subgroup analyses in a long-term follow-up of a previous trial, as well as new trials on patients with idiopathic th...

journal_title：Current opinion in pulmonary medicine

authors： Schulman S

更新日期：2000-07-01 00:00:00

abstract：:Small cell lung cancer (SCLC) accounts for 20% to 25% of bronchogenic carcinoma cases. Combination chemotherapy offers the best chance for improved survival. Cisplatin plus etoposide appears to be the most reasonable choice for first line therapy. Increasing dose intensity, although sometimes associated with higher re...

journal_title：Current opinion in pulmonary medicine

authors： Adjei AA

更新日期：2000-07-01 00:00:00

abstract：:Tuberculosis is currently an enormous global health problem. In industrialized countries in Western Europe and North America, tuberculosis case rates are low and an increasing proportion of cases now occur in foreign-born individuals and in marginalized populations, including the homeless, prisoners, drug users, and p...

journal_title：Current opinion in pulmonary medicine

authors： Johnson JL,Ellner JJ

更新日期：2000-05-01 00:00:00

abstract：:Pulmonary disease remains a major problem for the 33 million individuals who are thought to be infected with human immunodeficiency virus (HIV) worldwide. Respiratory infections are responsible for a large number of the 2 million deaths that occur each year in association with HIV disease. In countries where the major...

journal_title：Current opinion in pulmonary medicine

authors： Ashley EA,Johnson MA,Lipman MC

更新日期：2000-05-01 00:00:00

abstract：:Lung volume reduction surgery (LVRS) is a palliative surgical procedure for patients with severe emphysema. Resection of nonfunctional emphysematous lung tissue has been reported to relieve breathlessness and to improve quality of life for many patients by improving lung elastic recoil, respiratory muscle function, an...

journal_title：Current opinion in pulmonary medicine

authors： Meyer KC,Cornwell RD,Love RB

更新日期：2000-03-01 00:00:00

abstract：:An important advance in our understanding of the pathophysiology of asthma has been the discovery that airway inflammation is not confined to severe asthma but also characterizes mild and moderate asthma. Inflammation in asthma may be the result of a peculiar type of lymphocytic inflammation whereby Th2 lymphocytes se...

journal_title：Current opinion in pulmonary medicine

authors： Fahy JV,Corry DB,Boushey HA

更新日期：2000-01-01 00:00:00

abstract：:The goal of management of patients with respiratory failure is to restore them to a state of quiet breathing, without complication. This goal is often achieved by pharmacotherapy alone. Inhaled albuterol sulfate, oxygen, and systemic corticosteroids are mainstays of acute care drug management, whereas other data suppo...

journal_title：Current opinion in pulmonary medicine

authors： Gluckman TJ,Corbridge T

更新日期：2000-01-01 00:00:00

abstract：:Diabetes is a common complication of cystic fibrosis. Because it is associated with increased morbidity and mortality, prompt diagnosis and aggressive management of cystic fibrosis-related diabetes is important. The Cystic Fibrosis Foundation held a consensus conference in 1998 to define the standards of care for pati...

journal_title：Current opinion in pulmonary medicine

authors： Riggs AC,Seaquist ER,Moran A

更新日期：1999-11-01 00:00:00

abstract：:Recently, with radiology some advances have been made in the care of patients with interstitial lung disease, predominately through the use of high-resolution computed tomography. This technique is helpful not only in the diagnosis of interstitial lung disease, but also in patient follow-up and management. Other techn...

journal_title：Current opinion in pulmonary medicine

authors： Wilcox AG

更新日期：1999-09-01 00:00:00

abstract：:Pulmonary embolism occurs in more than 175,000 patients each year in the United States. The objectives of treatment are to prevent death from the existing embolus, to prevent death and morbidity from recurrent pulmonary embolism, and to prevent morbidity from recurrent deep-vein thrombosis. For patients with adequate ...

journal_title：Current opinion in pulmonary medicine

authors： Raskob GE

更新日期：1999-07-01 00:00:00

abstract：:In reviewing recent advances in upper respiratory tract infections, we focus on five key topics. First, the use of ribavirin in the treatment of respiratory syncytial virus infection has been limited to the immunosuppressed. Prophylaxis in high-risk patients with specific immunoglobulin is effective and a new monoclon...

journal_title：Current opinion in pulmonary medicine

authors： Moore DA,Sharland M,Friedland JS

更新日期：1999-05-01 00:00:00

abstract：:One aim of caring for adults and children with asthma should be the identification and treatment of the functional impairments that are troublesome to these patients in their daily lives. Studies have shown that correlations between measures of clinical asthma severity and control and health-related quality of life (H...

journal_title：Current opinion in pulmonary medicine

authors： Juniper EF

更新日期：1999-03-01 00:00:00

abstract：:Wheezing in infants and children presents a difficult differential diagnosis contingent on the presenting symptoms and age of the child. A determination of the anatomy of the lower airway, combined with allergic, infectious, and noninfectious irritants, is requisite to a complete evaluation. The intervention strategie...

journal_title：Current opinion in pulmonary medicine

authors： Chipps BE,Chipps DR

更新日期：1999-01-01 00:00:00

abstract：:Considerable progress has been made over the past 2 decades in defining and measuring health-related quality of life (QOL), and there is a growing recognition that these measures provide unique information about the impact of a chronic illness and its treatment. For patients with cystic fibrosis (CF), health-related Q...

journal_title：Current opinion in pulmonary medicine

authors： Quittner AL

更新日期：1998-11-01 00:00:00

abstract：:It is usually assumed that upper airway pressure receptors mediate the reflexes involved in sleep apneas, but many other receptors may be involved, including those responding to chemical stimuli. The reflexes to upper airway negative pressure have been further studied, and the timing of their inputs shown to be import...

journal_title：Current opinion in pulmonary medicine

authors： Widdicombe J

更新日期：1998-11-01 00:00:00

abstract：:Apoptosis, also known as activation-induced cell death or programmed cell death, is an active suicide mechanism that is involved in normal tissue turnover during embryogenesis and adult life. There are many examples of apoptosis in the immune system, including programmed cell death of T cells during negative intrathym...

journal_title：Current opinion in pulmonary medicine

authors： Agostini C,Perin A,Semenzato G

更新日期：1998-09-01 00:00:00

abstract：:Thoracoscopy has received increasing attention over the past decade as a result of the considerable advances that have been made in the development of endoscopic instruments. In contrast to the newly established video-assisted thoracoscopic surgery, the classic way to perform thoracoscopy is using only local anesthesi...

journal_title：Current opinion in pulmonary medicine

authors： Loddenkemper R,Schönfeld N

更新日期：1998-07-01 00:00:00

abstract：:Antibiotic resistance in respiratory pathogens has dramatically increased during recent years. Resistance to penicillin and multiple antimicrobial agents in pneumococci and resistance to ampicillin in Moraxella catarrhalis and Haemophilus influenzae, as a result of betalactamase production, have become highly prevalen...

journal_title：Current opinion in pulmonary medicine

authors： Dominguez MA,Pallares R

更新日期：1998-05-01 00:00:00

abstract：:The bronchiolitides can be categorized broadly as constrictive or proliferative, each with characteristic CT features. The cardinal CT signs of constrictive bronchiolitis are mosaic perfusion, enhanced on expiratory CT scan and variably associated with bronchiectasis and, less frequently, centrilobular branching struc...

journal_title：Current opinion in pulmonary medicine

authors： Wells AU

更新日期：1998-03-01 00:00:00

abstract：:Although asthma is considered to be an inflammatory disease of the airways, neural mechanisms remain very important. Neural control of airways is far more complex than has been previously recognized. In addition to the classic neural pathways, the nonadrenergic, noncholinergic pathway has been described in the airways...

journal_title：Current opinion in pulmonary medicine

authors： Choi DC,Kwon OJ

更新日期：1998-01-01 00:00:00

abstract：:As the number of inhaled drugs available for cystic fibrosis grows, there is increasing awareness of delivery device issues. Current jet and ultrasonic nebulizers are inefficient at delivering drugs to the lower respiratory tract. There are large differences in output characteristics between nebulizers and high inters...

journal_title：Current opinion in pulmonary medicine

authors： Geller DE

更新日期：1997-11-01 00:00:00

abstract：:The author describes a current status of nuclear imaging in interstitial lung disease. A number of tests have been proposed for the evaluation of disease activity. The only one that is used in many centers, however, is 67Ga scan. If the goal is the evaluation of functional impairment, 99mTc-penta-acetic acid aerosol m...

journal_title：Current opinion in pulmonary medicine

authors： Rizzato G

更新日期：1997-09-01 00:00:00

abstract：:Intrathoracic neoplasms other than bronchogenic carcinoma comprise a disparate group of tumors that have in common an anatomic location within the thorax. For the purposes of this review, they are divided into three categories: pulmonary metastases from locations other than the thorax, mediastinal neoplasms, and unusu...

journal_title：Current opinion in pulmonary medicine

authors： Yoneda KY,Tharratt RS

更新日期：1997-07-01 00:00:00

abstract：:Patients infected with HIV are at risk of developing a variety of infectious and malignant pleuropulmonary disorders. The three most common causes of AIDS-related pleural effusions are parapneumonic effusions or empyemas, tuberculosis, and Kaposi's sarcoma. However, the relative frequency of these conditions varies fr...

journal_title：Current opinion in pulmonary medicine

authors： Hamm H,Matthys H

更新日期：1997-07-01 00:00:00

abstract：:Many individuals are now surviving their injuries to face the consequences of an activated immunoinflammatory system and the complications of supportive therapy. The pulmonary system bears the force of this insult. An understanding of the epidemiology of acute respiratory failure, as well as a greater knowledge of the...

journal_title：Current opinion in pulmonary medicine

authors： O'Keefe GE,Maier RV

更新日期：1997-05-01 00:00:00

abstract：:The nontuberculous mycobacteria (NTM), especially Mycobacterium avium complex, are being recognized with increasing frequency as clinical pathogens, not only as a cause of disseminated disease in patients with AIDS but also as a cause of chronic lung disease in patients without AIDS. These infections have traditionall...

journal_title：Current opinion in pulmonary medicine

authors： Griffith DE

更新日期：1997-03-01 00:00:00

abstract：:There has been increased recognition of the importance of inflammatory cells and their products in the pathogenesis of asthma. From this recognition has evolved a number of new approaches to treat the various components of the asthmatic inflammatory response. Nonselective anti-inflammatory agents such as cyclosporine ...

journal_title：Current opinion in pulmonary medicine

authors： Floreani AA,Rennard SI

更新日期：1997-01-01 00:00:00

abstract：:The 24-hour properties of sleepiness affect behavior by reducing performance and increasing the likelihood of accidents. This is important to pulmonary physicians who diagnose and treat sleep apnea, because diagnoses of sleep apnea and narcolepsy are associated with as much as a sevenfold increase in the risk of havin...

journal_title：Current opinion in pulmonary medicine

authors： Mitler MM

更新日期：1996-11-01 00:00:00

abstract：:Pulmonary function changes in interstitial lung disease are characterized by loss of lung volume, increase in ratio of forced expiratory volume in 1 second to forced vital capacity, and decrease in carbon monoxide diffusion capacity. Recent developments in the assessment of respiratory mechanics in infiltrative lung d...

journal_title：Current opinion in pulmonary medicine

authors： Baydur A

更新日期：1996-09-01 00:00:00

abstract：:The diagnosis, staging, and follow-up of lung cancer is a clinical and therapeutic challenge. Recent radiographic advances are critical to the management of patients with lung cancer. This review focuses on state-of-the-art chest imaging modalities, including plain radiography, computed tomography; magnetic resonance ...

journal_title：Current opinion in pulmonary medicine

authors： Sarinas PS,Chitkara RK,Rizk NW,Segall GM,Stark P

更新日期：1996-07-01 00:00:00

abstract：:Thoracic empyema remains a significant medical problem in 1996. Patients in whom empyema develops suffer significant morbidity, frequently require prolonged hospitalizations, and are at an increased risk of death. In this review of parapneumonic effusions and empyema, four topics are discussed: diagnosis of empyema, t...

journal_title：Current opinion in pulmonary medicine

authors： Sasse SA

更新日期：1996-07-01 00:00:00

abstract：:Parapneumonic effusions are frequent complications of bacterial pneumonia. Depending on the severity of the underlying pneumonia, the promptness of antibiotic therapy, and the virulence of the infecting organism, 5% to 50% of patients will require pleural fluid drainage to prevent progression to an empyema. The decisi...

journal_title：Current opinion in pulmonary medicine

authors： Heffner JE

更新日期：1996-05-01 00:00:00

abstract：:Chronic obstructive pulmonary disease is the fourth leading cause of death in the United States, affecting approximately 10% of all adults. Several articles published during the past year contributed significantly to our understanding of the complicated management of this disease. New information concerning bronchodil...

journal_title：Current opinion in pulmonary medicine

authors： Navin DM,Gross NJ

更新日期：1996-03-01 00:00:00

abstract：:We review recently published literature on behavioral aspects of asthma, including program descriptions, reviews, and original research reports. Most of the literature on behavioral aspects of asthma has been in the area of self-management, including education, medication use, and peak flow monitoring. Recent studies ...

journal_title：Current opinion in pulmonary medicine

authors： Kohler CL,Davies SL,Bailey WC

更新日期：1996-01-01 00:00:00